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Pharmacokinetics icu setting_2007_nagoya
- 1. / /
- 2. / /
- 3. 3
- 4. 4
- 5. 5
- 6. 6
- 7. 7
- 8. 8
- 9. 9 L
- 10. 10 L 100mg 2μg/ml(=2mg/L) 100(mg)/2(mg/L)=50L 1kg 1L
- 11. 11
- 12. 12 (L)= (mg)/ (mg/L) Vd (L/kg) 0.3 0.5-1 >1
- 13. 13
- 14. 14
- 15. 15
- 16. 16 1-1.5mg/kg 17mg/kg
- 17. 17 1.5mg/kg × 10 50kg Vd ×Vd 50kg×1.1L/kg L kg×1.5mg/kg× mg mg / L mg/L =μg/ml
- 18. 18 1.5mg/kg × 50kg Vd Vd=1.1L/kg ×Vd 50kg×1.1L/kg 55 L kg×1.5mg/kg× 150 mg 150 mg / 55 L 2.7 mg/L =μg/ml 2-5μg/ml
- 19. 19 17mg/kg 3.6 30 50kg Vd ×Vd 50kg×1.9L/kg L kg×17mg/kg mg mg / L mg/L =μg/ml
- 20. 20 17mg/kg 50kg Vd Vd=1.9L/kg ×Vd 50kg×1.9L/kg 95 L kg×17mg/kg 850 mg 850 mg / 95 L 8.95 mg/L =μg/ml 4-10μg/ml
- 21. 21 50kg 250mg 50kg Vd ×Vd 50kg×0.5L/kg L 250mg mg / L mg/L =μg/ml →
- 22. 22 50kg 250mg 50kg Vd Vd=0.5L/kg ×Vd 50kg×0.5L/kg 25 L 250mg 250 mg / 25 L 10 mg/L =μg/ml 5-15μg/ml >20μg/ml → 10μg/ml 20μg/ml
- 23. 23 1-1.5mg/kg 17mg/kg
- 24. 24
- 25. 25
- 26. 26 (CCB) loading dose
- 27. 27
- 28. 28 4 5
- 29. 29 4 5 95%
- 30. 30
- 31. 31 H2 blocker iatrogenic
- 32. 32 4 iatrogenic