THE FOLLOWING PPT CONTAINS ALL IMPORTANT POINTS REGARDING SEPTIC SHOCK- PATHOGENESIS, SOFA AND QSOFA SCORE, CLINICAL FEATURES AND DETAILED MANAGEMENT.

1. PATHOGENESIS AND
MANAGEMENT OF SEPTIC
SHOCK
-DISHA SHEORAN
36

2. Shock is a systemic state of low tissue perfusion that is
inadequate for normal cellular respiration which results
in anaerobic metabolism and may result to cell death
and multi-organ failure if perfusion is not restored.

3. SEPTIC SHOCK
oIt results from moderate to severe sepsis or tissue damage.
oIt is considered as a part of a spectrum and a progression of SIRS
(Systemic Inflammatory Response Syndrome).
oSepsis is life-threatening organ dysfunction caused by a dysregulated
host response to infection identified by the presence of 2 or more
SOFA points [Sequential (sepsis related) organ failure assessment].
oQuick SOFA (qSOFA) score is also used which has the following
components-
1. Hypotension <100 mmHg
2. Tachypnea >22/minute
3. Altered mentation- GCS<13.

5. AETIOLOGY
Gram Positive Gram negative
• Clostridium tetani/welchii,
Staphylococci, Streptococci
and Pneumococci.
• Due to exotoxins.
• E. coli (most common),
Klebsiella, Pseudomonas etc.
• Due to endotoxins, therefore
aka Endotoxic shock.
• Viral, fungal and parasitic infections are rare, mostly in
immunocompromised patients.

7. PATHOGENESIS
Toxins/endotoxins from organisms like E. coli, Klebsiella
Inflammation, cellular activation of macrophages, neutrophils, monocytes
Release of cytokines, free radicals
Chemotaxis of cells, endothelial injury, altered coagulation
cascade-SIRS
Reversible hyperdynamic warm stage of septic shock with
fever, tachycardia, tachypnoea

8. Severe circulatory failure with MODS (failure of lungs,
kidneys, liver, heart) with DIC
Hypodynamic, irreversible cold stage of septic shock.

9. CLINICAL FEATURES
oBased on the magnitude of infection-
1. Mild sepsis which shows fever, tachycardia, leukocytosis.
2. Severe sepsis which shows low tissue perfusion with organ
dysfunction (lactic acidosis, dysfunction of liver, kidney, lungs).
3. Septic shock with systemic hypotension (BP <90 mm Hg in spite of
adequate fluid therapy), severe organ dysfunction (acute lung, kidney,
liver injury), maldistribution of blood flow, shunting in
microcirculation. Serum lactate level is >2 mmol/L. Despite adequate
resuscitation, a patient requires vasopressors to maintain MAP ~65
mmHg.

10. STAGES OF SEPTIC SHOCK
[I] HYPERDYNAMIC (WARM) STAGE-
oThis stage is reversible.
o Patient is still having inflammatory response and so presents with
fever, tachycardia, and tachypnoea.
oPyrogenic response is still intact.
oBased on blood culture, urine culture (depending on the focus of
infection), higher antibiotics like third generation cephalosporins,
aminoglycosides, metronidazole are started.
oTreatment of the underlying cause.
oVentilatory support with ICU monitoring.

11. [II] HYPODYNAMIC HYPOVOLEMIC SEPTIC SHOCK (COLD)-
oIn this stage the pyrogenic response is lost.
oPatient is in decompensated shock.
oIt is an irreversible stage along with MODS (multiorgan dysfunction
syndrome) with anuria, respiratory failure (cyanosis), jaundice (liver failure),
cardiac depression, pulmonary oedema, hypoxia, drowsiness, eventually
coma and death occurs (Irreversible stage).

12. TREATMENT
oIt is a medical emergency therefore, patient should be shifted to the
ICU (if possible).
oThe aim of the treatment is-
1. Improving hemodynamic state.
2. Restore tissue perfusion thereby increasing O2 delivery to tissues.
3. Administer O2.
4. Combat the bacteria and cytokines.
5. Eliminate septic focus.

13. Volume Replacement
oSecure i.v. access with 2 wide-bore cannulas and take samples for
CBC, EUCr.
oA crystalloid bolus of 30 mL/kg is recommended within 3 hours of
detecting severe sepsis or septic shock.
oA catheter is passed to empty the bladder and then monitor the hourly
urine output.
oVasopressor therapy is a fundamental treatment of septic shock-
induced hypotension as it aims at correcting the vascular tone
depression and then at improving organ perfusion pressure. Dopamine
(2-20µg/min) and Nor Adrenaline (5-20µg/min) are first line
vasopressors used. Terlipressin, epinephrine etc. are second line
agents.

14. Oxygen Therapy
oIn a cleared and patent airway, Oxygen is delivered via a face mask to
increase Oxygen saturation.
Antibiotics
oLarge doses are required i.v. to combat infection.
oCeftriaxone 50-100mg/kg upto 2g/day
+
Metronidazole 500 mg Q8H

15. Steroids
oShort-term (one or two doses) high dose steroid therapy- single dose
of methylprednisolone or dexamethasone which often may be repeated
again after 4 hours is said to be effective in endotoxic shock.
Treat the cause or focus
oDrainage of an abscess; laparotomy for peritonitis; resection of
gangrenous bowel; wound excision, peritoneal lavage etc.
Pus/urine/discharge/bile/blood culture and sensitivity for antibiotics.
-Activated C protein.
-Monitoring the patient by pulse oximetry, cardiac status, urine output,
ABG.

16. THANK YOU