2. Introducing Invetech
A synergistic mix of biomedical, automation, high
precision, fluid handling and user experience ...
All the right ingredients for bioprinting!
More than 30 years of product realization
Page 2
Diagnostics Cell TherapyPoint of Care
Consumer
& Industrial
8. Page 8
Making Human Tissue
Step 2 – The Bioprinter prints layers of Cell aggregates and BioGel
Extruded BioGel
lines
Cartridge with BioGel
or cell aggregates
3D print
nozzle
9. Page 9
Making Human Tissue
Step 3 – Construct is placed into a bioreactor and incubated
10. The NovoGen MMX Bioprinter™
Key features
Page 10
• 3 high-precision motion
axes
• Dual print heads for
BioGel and cell layers
• Thermal control of the
BioGel
• Semi-automated loading
of print cartridges
• An intuitive GUI for rapid
vessel/tissue design
11. The NovoGen MMX Bioprinter™
Initial blood vessel printing on the Bioprinter
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500 μm glass
cartridge
dispense tip
BioGel structure
containing BioGel and
cell lines
Blood vessel
geometry within the
BioGel structure
12. Simple Operation
Intuitive graphical user interface (GUI)
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WPF-based flexible GUI - customisable for future applications
Key focus is easy translation of simple tissue designs into real tissue
“mine sweeper” style designer for developing 2D geometric forms
Built-in scripting language for design of more complex 3D constructs
13. Simple Operation
Cartridge loading & alignment
Page 13
Before the Bioprinter …
Blood vessel printing took 8 hours or more
With the Bioprinter – less than an hour
Cartridge loading & alignment took up to 45 mins
With the Bioprinter - less than 1 minute
Thanks to ...
Intuitive cartridge loading with precision
alignment
Automatic positive displacement dispense
Automatic laser calibration of cartridge tip
position
14. Precision Printing
What’s needed for successful printing?
Page 14
Positional precision of better than ± 20 microns
Re-calibration of tip positions for each cartridge
Smooth dispense of cells and BioGel
Bio-compatible operation
100 µm human hair
15. Precision Printing
How it’s done …
Page 15
Optical-grade robotic axes with single micron precision
Novel 3D laser tip calibration using custom interpolation algorithms
Closed loop micro-stepping motor control to minimize vibration
Designed for the bio-safety cabinet
16. From Science to Application
A timeline from the first blood vessel
Page 16
December 2010
First human blood vessel
Time Magazine’s Best Inventions of 2010
Mar 2011
Partnerships with big pharma
Nov 2011
Australian Engineering Innovation Award.
Dec 2012
Autodesk partnership
Feb 2013
Refined Bioprinters delivered to Organovo
17. From Science to Application
A timeline from the first blood vessel
Page 17
Apr 2013
First 3D liver tissue. Life span increases from 5 to 40 days
Apr 2014
Contracting for 3D liver tissue toxicity testing
The Near Future
3D tissue constructs replace existing pre-clinical trial methods for drug screening.
Simple tissues start being used for direct surgical therapy
18. Alternate Blood Vessel Manufacturing
Page 18
“Off the shelf” human veins for use in life-saving vascular surgery
Humacyte Artificial Vascular Graft (HAVGTM)