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MACROMOLECULES 
BUILDING BLOCKS OF LIFE
BIOLOGICAL MOLECULES 
YOU ARE WHAT YOU EAT CRASH COURSE 
BIOLOGY #3
MACROMOLECULES 
• Known as organic compounds 
• Built around the element carbon 
• Large molecules are called macromolecules 
• “Macro” – meaning large 
• Polymer 
• Made by smaller molecules bonding together called 
monomers
DRAW A PICTURE 
MONOMER POLYMER 
“ONE” “MANY”
EXAMPLES OF POLYMERS 
• A fiber is a long thread-like structure 
• Natural polymers include hair, fur, wool 
• Proteins 
• Monomer is an amino acid 
• Silk made by some insects and spiders 
• Cotton is a vegetable fiber 
• Cotton is composed of cellulose (polymer) 
• Monomer is glucose (a sugar)
MACROMOLECULES FORMED 
• All macromolecules put their subunits together in the same 
way 
• Covalent bond of OH is removed from one subunit and a H is 
removed from the others 
• Removal of a water molecule 
• Requires help of special protein enzyme to position the molecule 
to make sure the correct bond is formed 
• Called dehydration synthesis 
• Tearing down molecules is the same process in reverse 
• Water molecule is added 
• Called hydrolysis
BIOLOGICAL MOLECULES 
YOU ARE WHAT YOU EAT CRASH COURSE 
BIOLOGY #3
CARBOHYDRATES 
• Sugars or long chains of sugars 
• Store energy 
• Simple sugars 
• Monosaccharides (monomer) 
• Glucose 
• Complex sugars 
• Polysaccharides (polymer) 
• Plant 
• Starch 
• Animals 
• Glycogen 
• Energy storage by linking chains together 
• Not recognized by most enzymes
BIOLOGICAL MOLECULES 
YOU ARE WHAT YOU EAT CRASH COURSE 
BIOLOGY #3
LIPIDS 
• Uses: 
• Long-term energy storage 
• Insulation (keep warm) 
• Cushions organs (heart, eyes, kidney, etc.) 
• Lipids 
• Fats 
• Oils 
• Waxes
LIPIDS 
• Organisms convert glucose into fats 
• Another kind of storage molecule called glycogen 
• Lipids are insoluble in water because they are non-polar 
• In water, fat molecules cluster together because they cannot 
form Hydrogen bonds with water molecules 
• Can’t mix oil and water!
TYPES OF LIPIDS 
• Monomer – fatty acids 
• Types of Lipids 
• Triglyceride 
• 3 fatty acids 
• Saturated fat 
• Maximum number of Hydrogen atoms bonded 
• Solid at room temperature 
• Animal fats 
• Unsaturated fat 
• Fewer than maximum number of Hydrogen atoms bonded 
• Liquid at room temperature 
• Plant fats
TYPES OF LIPIDS 
• Phospholipid 
• Polar group on one end 
• 2 long tails that are strongly non-polar 
• Cell membrane 
• Phospholipid bilayer 
• Steroid 
• Yellow structure in cell membrane 
• Cholesterol 
• Excess saturated fat intake can cause plugs of cholesterol in blood 
vessels 
• Cause blockages, high blood pressure, stroke or heart attack 
• Androgens and Estrogen 
• Chlorophyll 
• Retinal (eyes use to detect light)
BIOLOGICAL MOLECULES 
YOU ARE WHAT YOU EAT CRASH COURSE 
BIOLOGY #3
PROTEINS 
• Enzymes 
• Cartilage 
• Bones 
• Tendons 
• Keratin 
• Chemical messenger
PROTEINS 
• Monomer – amino acid 
• 20 common kinds 
• Sequenced together in a particular order to form a protein 
• Like the alphabet 
• Amine group (NH2) 
• When 2 amino acids bond a peptide bond is formed 
• Long changes are polypeptides 
• Connect like beads on a necklace 
• Example: hemoglobin in red blood cells
PROTEINS 
• 100,000+ unique proteins to humans 
• Shape 
• Some are long, thin fibers 
• Others are coiled, folded, or intertwined 
• Small proteins have a few hundred amino acids 
• Large proteins have 25,000+ amino acids 
• Example: muscle fiber
PROTEINS 
• People must eat foods with proteins because we CANNOT 
make certain amino acids on our own 
• Called essential amino acids 
• Sources of protein: 
• Plants 
• Beans 
• Nuts 
• Animals 
• Milk 
• Meat
PROTEINS 
• Eat  Body breaks down* (Digestion)  Amino Acid  Build 
new proteins  Repair 
You are what you eat! 
* Denatures the protein by increasing temperature or 
decreasing pH.
NUCLEIC ACIDS 
• Monomer: Nucleotide 
• Sugar, nitrogen-containing back and a phosphate group 
• Polynucleotide chains 
• Deoxyribonucleic Acid (DNA) 
• Ribonucleic Acid (RNA) 
• Adenosine Triphosphate (ATP) 
• Energy 
• DNA and RNA are very similar but have 2 major chemical 
differences

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Macromolecules Notes

  • 2. BIOLOGICAL MOLECULES YOU ARE WHAT YOU EAT CRASH COURSE BIOLOGY #3
  • 3. MACROMOLECULES • Known as organic compounds • Built around the element carbon • Large molecules are called macromolecules • “Macro” – meaning large • Polymer • Made by smaller molecules bonding together called monomers
  • 4. DRAW A PICTURE MONOMER POLYMER “ONE” “MANY”
  • 5. EXAMPLES OF POLYMERS • A fiber is a long thread-like structure • Natural polymers include hair, fur, wool • Proteins • Monomer is an amino acid • Silk made by some insects and spiders • Cotton is a vegetable fiber • Cotton is composed of cellulose (polymer) • Monomer is glucose (a sugar)
  • 6. MACROMOLECULES FORMED • All macromolecules put their subunits together in the same way • Covalent bond of OH is removed from one subunit and a H is removed from the others • Removal of a water molecule • Requires help of special protein enzyme to position the molecule to make sure the correct bond is formed • Called dehydration synthesis • Tearing down molecules is the same process in reverse • Water molecule is added • Called hydrolysis
  • 7. BIOLOGICAL MOLECULES YOU ARE WHAT YOU EAT CRASH COURSE BIOLOGY #3
  • 8. CARBOHYDRATES • Sugars or long chains of sugars • Store energy • Simple sugars • Monosaccharides (monomer) • Glucose • Complex sugars • Polysaccharides (polymer) • Plant • Starch • Animals • Glycogen • Energy storage by linking chains together • Not recognized by most enzymes
  • 9. BIOLOGICAL MOLECULES YOU ARE WHAT YOU EAT CRASH COURSE BIOLOGY #3
  • 10. LIPIDS • Uses: • Long-term energy storage • Insulation (keep warm) • Cushions organs (heart, eyes, kidney, etc.) • Lipids • Fats • Oils • Waxes
  • 11. LIPIDS • Organisms convert glucose into fats • Another kind of storage molecule called glycogen • Lipids are insoluble in water because they are non-polar • In water, fat molecules cluster together because they cannot form Hydrogen bonds with water molecules • Can’t mix oil and water!
  • 12. TYPES OF LIPIDS • Monomer – fatty acids • Types of Lipids • Triglyceride • 3 fatty acids • Saturated fat • Maximum number of Hydrogen atoms bonded • Solid at room temperature • Animal fats • Unsaturated fat • Fewer than maximum number of Hydrogen atoms bonded • Liquid at room temperature • Plant fats
  • 13. TYPES OF LIPIDS • Phospholipid • Polar group on one end • 2 long tails that are strongly non-polar • Cell membrane • Phospholipid bilayer • Steroid • Yellow structure in cell membrane • Cholesterol • Excess saturated fat intake can cause plugs of cholesterol in blood vessels • Cause blockages, high blood pressure, stroke or heart attack • Androgens and Estrogen • Chlorophyll • Retinal (eyes use to detect light)
  • 14. BIOLOGICAL MOLECULES YOU ARE WHAT YOU EAT CRASH COURSE BIOLOGY #3
  • 15. PROTEINS • Enzymes • Cartilage • Bones • Tendons • Keratin • Chemical messenger
  • 16. PROTEINS • Monomer – amino acid • 20 common kinds • Sequenced together in a particular order to form a protein • Like the alphabet • Amine group (NH2) • When 2 amino acids bond a peptide bond is formed • Long changes are polypeptides • Connect like beads on a necklace • Example: hemoglobin in red blood cells
  • 17. PROTEINS • 100,000+ unique proteins to humans • Shape • Some are long, thin fibers • Others are coiled, folded, or intertwined • Small proteins have a few hundred amino acids • Large proteins have 25,000+ amino acids • Example: muscle fiber
  • 18. PROTEINS • People must eat foods with proteins because we CANNOT make certain amino acids on our own • Called essential amino acids • Sources of protein: • Plants • Beans • Nuts • Animals • Milk • Meat
  • 19. PROTEINS • Eat  Body breaks down* (Digestion)  Amino Acid  Build new proteins  Repair You are what you eat! * Denatures the protein by increasing temperature or decreasing pH.
  • 20. NUCLEIC ACIDS • Monomer: Nucleotide • Sugar, nitrogen-containing back and a phosphate group • Polynucleotide chains • Deoxyribonucleic Acid (DNA) • Ribonucleic Acid (RNA) • Adenosine Triphosphate (ATP) • Energy • DNA and RNA are very similar but have 2 major chemical differences