Amelogenesis is the formation of enamel. During amelogenesis, the ameloblast (enamel-forming cells) undergo various stages i.e the life cycle of ameloblast. For more content check out my blog: www.rkharitha.wordpress.com "a little about everything dental"

1. Life Cycle Of Ameloblast

2. What are Ameloblasts?
• Ameloblasts are cells present only during
tooth development that deposit tooth enamel,
which is the hard outermost layer of the tooth
forming the surface of the crown.

3. Life Cycle Of Ameloblast
Life cycle of ameloblast divided into 6 stages
depending upon their function
1. Morphogenic stage
2. Organising stage
3. Formative stage
4. Maturative stage
5. Protective stage
6. Desmolytic stage

4. Morphogenic stage
• Cell short columnar
• Large oval nucleus
• Cytoplasm is less
organelles is less
• Organelles – mitochondria
centrioles
golgi apparatus

5. Organising stage
• Cells become
Longer
• Reversal of
Polarity
• Redistribution of
cytoplasmic
organelles
• Reversal of
nutrition stream

6. Formative stage
• This stage starts after first
layer of Dentin is laid down
• Development of tome’s
process
• Rods and interrods formation
• Functional unit of enamel is
rod.
• Key hole pattern

7. Cross section of ameloblast

8. Maturative stage
• Absorption of protein
and deposition of
minerals.
• Tome’s process
disappears
• Modulation cycle
• Helps in apposition

9. Modulation cycle
ruffled (60%)
transition (10%) transition (10%)
smooth (20%)

10. Ruffled and smooth ended ameloblast

11. Protective stage
• Radicular dentin formation
• Hertwig’s epithelial root
sheath breaks
• IEE and OEE looses support
and becomes fragments
• Cementum formation
• REE is broken – mineralised
enamel in contact with
dental follicle

12. Desmolytic stage
• IEE stimulate dental follicle to
form osteoclasts activating factor
(OAF)
• Osteoclast
• Lysosomal enzymes
• Ligamentous connective tissue
and dental follicle degenerated
• Epithelial plug formation
• Epithelia degenerate since
absence of connective tissue
• Tooth eruption – no bleeding