Antibodies as Drugs

Antibodies as Drugs Lauren Lahey April 26, 2007

Overview ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Emerging Themes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

At the turn of the 20 th century: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

More recently: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Important Terms ,[object Object],[object Object],[object Object],[object Object],[object Object]

The Structure of an Antibody ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Formation of Disulfide Bonds ,[object Object],[object Object],[object Object],[object Object]

Compliment fixation First antibody secreted in development μ IgM Promotes antibody-dependent cellular cytotoxicity (ADCC) Compliment fixation Main antibody in serum Most Stable γ IgG Cells that secrete histamines ε IgE B Cell surface receptor δ IgD External Secretions or α IgA Biological Activity Distribution Diagram Heavy Chain Immunoglobulin (Ig) Class

Hypervariable Loops ,[object Object],[object Object],[object Object],[object Object],[object Object]

A Dynamic Binding Site ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Antibody Pharmokinetics ,[object Object],[object Object],[object Object],[object Object],[object Object]

Cross-linking ,[object Object],[object Object],[object Object],[object Object]

Mechanisms of Action ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

“Humanizing” Antibodies ,[object Object],[object Object],[object Object],[object Object],[object Object]

Production of Human Antibodies

Pharmaceutical Antibodies ,[object Object],[object Object],[object Object],[object Object],[object Object]

Nomenclature of Monoclonal Antibodies toxin as target -tox(a)- nervous system -neu(r)- miscellaneous tumor -tu(m)- prostate tumor -pr(o)- ovarian tumor -go(v)- testicular tumor -go(t)- mammary tumor -ma(r)- melanoma -me(l)- colonic tumor -co(l)- rat/murine hybrid -axo- interleukin -ki(n)- humanized -zu- musculoskeletal -mu(l)- chimeric -xi- cardiovascular -ci(r)- primate -i- infectious lesions -le(s)- hamster -e- immune -li(m)- rat -a- bacterial -ba(c)- mouse -o- viral -vi(r)- -mab human -u- bone -o(s)- variable Suffix Source Target Prefix

Autoimmune Disease ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Rheumatoid Arthritis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Infliximab ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Adalimumab ,[object Object],[object Object],[object Object],[object Object],[object Object]

Rituximab ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Interesting Variations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Nanobodies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

References ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Antibodies as Drugs

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