This document discusses nephrotoxicity, or drug-induced kidney damage. It notes several historical examples of humanitarian disasters caused by drugs like sulfanilamide and thalidomide. Drugs can directly or indirectly damage the urinary system, especially the tubules and glomeruli of the kidneys. Proper safety testing and rational drug use are important to prevent medical errors and protect patients.

1. NATIONAL UNIVERSITY OF PHARMACY
Department of Clinical Laboratory Diagnostic

10. ПіуріяПіурія
More than 60 in sight

15. E. coli in urine
(different
multiplicity
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18. The crystals of uric acid

19. Urate crystals

20. Crystals of tripelphosfats

21. Amorphous phosphate crystals

22. Crystals urine acid ammonium

23. Crystals phosphate of lime

24. Oxalate crystals

25. Crystals of cholesterol and bilirubin

32. Characteristics of the glomerular
filtration rate
Normally, men - 120 ± 25 ml / min, for
women - 95 ± 20 ml / min

35. In violation of the outflow of urine appears fever,
symptoms of intoxication, leukocytosis, leukocyte shift to
the left, increasing SHOЭ and anuria

38. «... The problem of the safety and efficacy of
medicinal products is becoming increasingly
important worldwide. This is due to the
introduction of the medical practice of a large
number of pharmacological agents, irrational
use of medicines, medical errors ... »
World Health Organization, 2006

39. Humanitarian disasters related to
drugs:
1937 - Mr. sulfanilamide in diyetylenhlykoli
1961 - thalidomide
1983 - zomepyrak
1983 - osmozyn
1982 - benoksaprofen
2001 - tseryvastatyn
2005 - problem koksybiv
2006 - problem antidepressants

41. Nephrotoxicity drugs or "drug
nephropathy" - direct or indirect
(via the immune response)
poshkodzhuyacha effect of drugs
on urinary system and, above all,
on tubular and glomerular
apparatus
Nephrotoxicity drugs or "drug
nephropathy" - direct or indirect
(via the immune response)
poshkodzhuyacha effect of drugs
on urinary system and, above all,
on tubular and glomerular
apparatus