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ePro Adaptive Design

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Using ePRO in Adaptive Trial Design CBI 4 th PRO Conference Dwight Cooper Global Director, Technical Services PHT Corporation (617) 973-1838 [email_address] 28 May 2009
Using ePRO in Adaptive Trial Design ,[object Object],[object Object],[object Object],[object Object],[object Object]
Traditional “Non-Adaptive” ePRO Design ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adapting ePRO Design via Mid Study Changes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adaptive Trial Design ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Types of Adaptive Trial Designs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adaptive Trial Design ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Barriers to Using Adaptive Designs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Benefits ePRO Provides for Adaptive Trials ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Example of an Adaptive ePRO Trial ,[object Object],[object Object],[object Object],[object Object],[object Object]
Example of an Adaptive ePRO Trial Adaptive branching logic for one daily dose Standard branching logic for two daily doses

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ePro Adaptive Design

  • 1. Using ePRO in Adaptive Trial Design CBI 4 th PRO Conference Dwight Cooper Global Director, Technical Services PHT Corporation (617) 973-1838 [email_address] 28 May 2009
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  • 11. Example of an Adaptive ePRO Trial Adaptive branching logic for one daily dose Standard branching logic for two daily doses