Curing life threatening diseases with bone marrow transplant

1. Curing life-threatening diseases
with bone marrow transplant
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2. Contd…
Dr Prashant Mehta, consultant and unit head, Medical Oncology
Hematoncology BMT, Asian Institute of Medical Sciences, says that bone
marrow transplantation is a misnomer most transplants are conducted by
harvesting stem cells (primitive cells in the bone marrow which form mature
blood cells like red blood cells, white blood cell and platelets) from the
donor's peripheral blood. So, the correct and logical term now is peripheral
blood stem cell transplantation. But the general perception that it's a surgical
procedure, because this is a staged medical procedure which takes about
four weeks and is carried out by a Medical Oncologist or a Hematoncologist.
There are two types of stem cell transplants Autologous (using patient's own
stem cells) and Allogenic (using a matched sibling, a matched unrelated
donor, cord blood or a partially matchedHaploidentical donor). HLA matching
is done for allogenic transplants using a blood sample or buccal swab of the
donor and the recipient.
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3. Contd…
Stem cell harvest is done from the blood of the patient in case of autologous
and the donor in case of an allogenic transplant, by using mo bilizing agents.
These stem cells are reinfused into the patient after high dose chemotherapy
to relieve the patient's marrow from the effects of high-dose chemotherapy .
Dr Mehta adds that autologous transplant is required for multiple myeloma
(standard for all fit patients below 65) and relapsed lymphomas.Allogenic
stem cell transplant can cure many blood cancers, where it's used for specific
indications (AML, ALL, CML) and is the only cure for some non-malignant life-
threatening diseases like thalassemia major, aplastic anemia, and inherited
metabolic disorders like Adrenoleukodystrophy and Hurler syndrome. Asian
Institute of Medical Sciences has a dedicated and state-of-the-art stem cell
transplantation centre which caters to blood cancers and stem cell
transplantation for non-malignant conditions.
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