This document discusses efforts by the Substance Abuse and Mental Health Services Administration (SAMHSA) to address prescription drug and opioid abuse through cross-system collaboration. SAMHSA supports prescriber and consumer education, prescription drug monitoring programs, and safe disposal of unused medicines. Specific SAMHSA programs mentioned include Partnerships for Success grants, prescription drug monitoring program grants, and screening and brief intervention programs. The document also outlines funding for medication assisted treatment, preventing opioid overdose deaths, and a strategic prevention framework for prescription drugs.