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Silver	Nanoparticles	Prevent	Replication	of	Hepatitis	B	Virus	
	
In	a	recent	study	conducted	by	scientists	at	the	University	of	
Hong	Kong,	it	was	demonstrated	in	vitro	that	very	tiny	silver	
particles	have	the	ability	to	interact	with	viral	DNA	in	such	a	
way	as	to	prevent	replication,	whether	the	virus	was	inside	
the	host	cells	(i.e.,	inside	human	cells,	where	viruses	would	
normally	replicate)	or	outside	the	host	cells.	
	
This	is	especially	important,	because	it	implies	that	silver	can	
not	only	prevent	viruses	from	infecting	cells,	but	can	also	
stop	cells	that	are	already	virally	infected	from	spreading	the	
infection.		
	
According	to	a	research	abstract	from	the	University	of	Hong	
Kong,	the	scientists	examining	the	action	of	silver	particles	on	
the	Hepatitis	B	virus	“hypothesize	that	the	direct	interaction	
between	these	nanoparticles	and	HBV	double-stranded	DNA	
or	viral	particles	is	responsible	for	their	antiviral	mechanism.”		
	
The	scientists	point	out	that	this	only	demonstrates	the	
effectiveness	of	very	tiny	silver	particles	against	the	HBV	(i.e.,	
hepatitis	B	virus),	and	not	necessarily	other	viruses.
Nevertheless,	once	again	we	have	a	study	demonstrating	conclusively	
that	very	tiny	particles	of	silver	have	the	ability	to	interfere	with	
viruses,	preventing	them	from	interacting	with	human	cells	and	causing	
infections.		
	
According	to	a	news	article	about	this	study,	the	researchers	discovered	
that:	
	
“…ultra-tiny	silver	particles	could	reduce	the	extracellular	DNA	
formation	of	HBVs	by	over	50	percent,	and	could	check	their	
intracellular	RNA	formation,	too.	
	
'Silver	nano-particles	have	special	properties	such	as	larger	active	
surface	and	porosity	so	that	they	can	easily	bind	with	small	molecules,'	
China's	XINHUA	news	agency	quoted	Lu	as	saying,	referring	to	a	
hypothetical	explanation	they	had	put	forward	on	the	new	antiviral	
mechanism.	
	
'The	finding	provides	a	new	direction	for	developing	new	anti-HBV	
drugs,	with	nano-particles	used	as	drug	carrier	to	enhance	the	antiviral	
efficacy	while	minimizing	the	undesirable	side	effects,'	Lu	told	a	press	
conference	Monday.	
	
The	young	researcher	said	there	are	currently	only	two	kinds	of	drugs
immunomodulators	and	nucleoside	analogues.	But	their	uses	are	
affected	by	side	effects	and	drug-resistant	mutations.	
	
Hepatitis	B	is	one	of	the	worst	killers	as	it	chronically	infects	over	400	
million	people	worldwide,	with	certain	developing	countries	and	
regions	hit	hardest.	
	
Lu	said	silver	nano-particles	have	an	additional	distinct	advantage.	It	
is	unlikely	that	HBV	can	become	resistant	to	silver	nano-particles	
because	the	interaction	is	determined	by	the	physiochemical	
properties	of	the	tiny	particles."	
	
In	other	words,	silver	not	only	helps	prevent	the	Hepatitis	B	virus	
from	infecting	cells,	but	it	also	helps	prevent	cells	that	are	already	
infected	from	spreading	the	infection.	And	it	does	so	by	interfering	
with	the	DNA	in	the	Hepatitis	B	virus.			
	
Finally,	the	researchers	concluded	that	unlike	prescription	antiviral	
drugs	which	can	lose	potency	against	the	Hepatitis	B	virus,	silver	is	
unlikely	to	do	so	because	of	its	unique	mode	of	action	against	the	
virus.

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Nano Silver prevents spread of viral infections